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What Every Pharmaceutical Lab Should Know About SamplePrep Precision

May 21, 2025

Sample preparation plays a critical role in pharmaceutical laboratories. From solid dosages like tablets to finished products, meticulous analysis is required, and the process begins with precision in your sample preparation.  This step ensures that the samples being analyzed produce results which are accurate and reproducible.

Why Precise SamplePrep is so Important

  • Homogenization: Achieving uniform particle size to ensure representative sampling.
  • Avoids Contamination: Preventing cross-contamination between samples.
  • Efficiency: Reducing preparation time without compromising accuracy.

Traditional methods, such as manual grinding with mortars and pestles, are time-consuming and prone to too much variability between batches. Modern laboratories require solutions that offer consistency, speed, and compliance with stringent regulatory standards. ATS Scientific offers a range of Retsch SamplePrep solutions which address these challenges. Here’s how:

1. Enhanced Homogeneity for Accurate Analysis

ATS offers a suite of Retsch instruments which ensure uniform particle size distribution, minimizing variability and enhancing the reliability of analytical results. This is crucial for methods like HPLC, NIR, and dissolution testing, where sample consistency directly impacts data integrity.

2. Minimized Contamination Risks

Utilizing components made from inert materials and offering closed-system processing, ATS provides solutions to contamination risks which help maintain the purity of samples, vital for accurate API quantification.

3. Optimized Efficiency and Throughput

Time is a critical factor in pharmaceutical analysis. Retsch's solutions streamline the sample preparation process, significantly reducing preparation time compared to traditional methods. This efficiency enables laboratories to handle higher sample volumes without compromising on quality.

4. Compliance with Regulatory Standards

Pharmaceutical laboratories operate under strict regulatory frameworks. Retsch's equipment is designed to meet these standards, offering features that support compliance with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) guidelines.

Pharmaceutical Sample Preparation Solutions from ATS

ATS boasts a suite of sample preparation instruments commonly used in the pharmaceutical industry.  Here we provide a few examples of ATS’s solutions designed to improve your sample preparation workflow:

·       Mixer Mills for homogenizing tablet components, mixing active ingredients (APIs) and cryogenic grinding for temperature sensitive materials

·       Centrifugal mills: for the preparation of granulates or powders for dissolution testing.  This is commonly used in pharmaceutical labs for the milling of raw plant materials for herbal medicine.

·       Cutting Mills: Ideal for SamplePrep of gel capsules and cutting up blister packs for analysis.

·       Cryogenic Mills: Designed for size reduction of oily samples while maintaining chemical stability of volatile compounds

·       Sieve Shakers: Ensures accurate quality control of powder formulas and essential for determining uniformity and granule size.

Exploring Sample Preparation Solutions for Your Laboratory?

Incorporating ATS's advanced sample preparation solutions into your laboratory workflow can lead to improved reliability of your analytical results, increase your lab’s productivity with faster preparation times, and regulatory confidence with a full range of equipment designed to ensure adherence to industry standards.

Whether you are upgrading your lab’s workflow or starting from scratch, ATS’s expertise and technology can help you with product recommendations to ensure your lab produces results which are precise, uniform and reproducible.